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  • 主办单位：
    中国光学工程学会清华大学上海理工大学
  • 名誉主编： 庄松林 院士
  • 国际主编： 顾敏 院士
  • 主       编：
    孙洪波 教授仇旻 教授
  • 创       刊：2020年3月
  • ISSN：2662-1991
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CMOS optoelectronic spectrometer based on photonic integrated circuit for in vivo 3D optical coherence tomography
Anja Agneter, Paul Muellner, Quang Nguyen, Dana Seyringer, Elisabet A. Rank, Marko Vlaskovic, Jochen Kraft, Martin Sagmeister, Stefan Nevlacsil, Moritz Eggeling, Alejandro Maese-Novo, Yevhenii Morozov, Nicole Schmitner, Robin A. Kimmel, Ernst Bodenstorfer, Pietro Cipriano, Horst Zimmermann, Rainer A. Leitgeb, Rainer Hainberger, Wolfgang Drexler
 doi: 10.1186/s43074-024-00150-7
Abstract(0) PDF(0)
Abstract:
Photonic integrated circuits (PICs) represent a promising technology for the much-needed medical devices of today. Their primary advantage lies in their ability to integrate multiple functions onto a single chip, thereby reducing the complexity, size, maintenance requirements, and costs. When applied to optical coherence tomography (OCT), the leading tool for state-of-the-art ophthalmic diagnosis, PICs have the potential to increase accessibility, especially in scenarios, where size, weight, or costs are limiting factors. In this paper, we present a PIC-based CMOS-compatible spectrometer for spectral domain OCT with an unprecedented level of integration. To achieve this, we co-integrated a 512-channel arrayed waveguide grating with electronics. We successfully addressed the challenge of establishing a connection from the optical waveguides to the photodiodes monolithically co-integrated on the chip with minimal losses achieving a coupling efficiency of 70%. With this fully integrated PIC-based spectrometer interfaced to a spectral domain OCT system, we reached a sensitivity of 92dB at an imaging speed of 55kHz, with a 6dB signal roll-off occurring at 2mm. We successfully applied this innovative technology to obtain 3D in vivo tomograms of zebrafish larvae and human skin. This ground-breaking fully integrated spectrometer represents a significant step towards a miniaturised, cost-effective, and maintenance-free OCT system.
Optical polarization manipulations with anisotropic nanostructures
Zhancheng Li, Wenwei Liu, Yuebian Zhang, Hua Cheng, Shuang Zhang, Shuqi Chen
 doi: 10.1186/s43074-024-00143-6
Abstract(8) PDF(3)
Abstract:
Over the past few decades, metasurfaces have revolutionized conventional bulky optics by providing an effective approach to manipulate optical waves at the subwavelength scale. This advancement holds great potential for compact, multifunctional, and reconfigurable optical devices. Notably, metasurfaces constructed with anisotropic nanostructures have exhibited remarkable capability in manipulating the polarization state of optical waves. Furthermore, they can be employed to achieve independent control of the amplitude and phase of optical waves in different polarization channels. This capability has garnered significant attention from the photonics community due to its unprecedented potential for polarization-selective and -multiplexed optical wave manipulation, offering versatile applications in optical imaging, communication, and detection. This paper reviews the design principles, representative works, and recent advancements in anisotropic nanostructures for optical polarization manipulation, detection, as well as polarization-selective and -multiplexed optical wave manipulation. Personal insights into further developments in this research area are provided.
Multimode communication with programmable photonic integrated mesh
Minjia Chen, Qixiang Cheng
 doi: 10.1186/s43074-024-00145-4
Abstract(7) PDF(30)
Abstract:
The programmable photonic integrated mesh is arising as a powerful tool to deal with crosstalk in the multimode optical communication link.
Multicolor single-molecule localization microscopy: review and prospect
Xi Chen, Xiangyu Wang, Fang Huang, Donghan Ma
 doi: 10.1186/s43074-024-00147-2
Abstract(11) PDF(1)
Abstract:
Single-molecule localization microscopy (SMLM) surpasses the diffraction limit by randomly switching fluorophores between fluorescent and dark states, precisely pinpointing the resulted isolated emission patterns, thereby reconstructing the super-resolution images based on the accumulated locations of thousands to millions of single molecules. This technique achieves a ten-fold improvement in resolution, unveiling the intricate details of molecular activities and structures in cells and tissues. Multicolor SMLM extends this capability by imaging distinct protein species labeled with various fluorescent probes, providing insights into structural intricacies and spatial relationships among different targets. This review explores recent advancements in multicolor SMLM, evaluates the strengths and limitations of each variant, and discusses the future prospects.
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Terahertz spectroscopy in biomedical field: a review on signal-to-noise ratio improvement
Yan Peng, Chenjun Shi, Yiming Zhu, Min Gu, Songlin Zhuang
2020, 1(1).    doi: 10.1186/s43074-020-00011-z
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Information Metamaterials: bridging the physical world and digital world
Qian Ma, Tie Jun Cui
2020, 1(1).    doi: 10.1186/s43074-020-00006-w
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Recent advances in multi-dimensional metasurfaces holographic technologies
Ruizhe Zhao, Lingling Huang, Yongtian Wang
2020, 1(1).    doi: 10.1186/s43074-020-00020-y
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Vacuum-ultraviolet photodetectors
Lemin Jia, Wei Zheng, Feng Huang
2020, 1(1).    doi: 10.1186/s43074-020-00022-w
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