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主办单位：
中国光学工程学会清华大学上海理工大学
名誉主编： 庄松林院士
国际主编： 顾敏院士
主编：
孙洪波教授仇旻教授
创刊：2020年3月
ISSN：2662-1991

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Characterization of cancer-associated adipocytes by Raman spectroscopy and trajectory inference

Nicolas Goffin, Emilie Buache, Nathalie Lalun, Marion Fernandes, Ines Miguel, Catherine Muller, Charlotte Vaysse, Landry Blanc, Cyril Gobinet, Olivier Piot

doi: 10.1186/s43074-024-00146-3

Abstract(0) PDF(0)

Abstract:
Cancer-associated adipocytes (CAAs) have emerged as pivotal players in various cancers, particularly in such as breast cancer, significantly influencing their progression and therapy resistance. Understanding the adipocytes/cancer cells crosstalk is crucial for effective treatment strategies. Raman spectroscopy, a label-free optical technique, offers potential for characterizing biological samples by providing chemical-specific information. In this study, we used Raman spectroscopy and Trajectory Inference methods, specifically the Partition-based graph abstraction algorithm, to investigate the interactions between 3T3-L1 differentiated adipocytes and MDA-MB-231 breast cancer cells in a 2D co-culture model. We demonstrate the existence of subpopulations of adipocytes and the molecular changes associated with CAAs phenotype. This work contributes to understanding the role of CAAs in breast cancer progression and may guide the development of targeted therapies disrupting this interaction.

Three-dimensional computer holography with phase space tailoring

Runze Zhu, Lizhi Chen, Jiasheng Xiao, Hao Zhang

doi: 10.1186/s43074-024-00149-0

Abstract(7) PDF(2)

Abstract:
Computer holography is a prominent technique for reconstructing customized three-dimensional (3D) diffraction fields. However, the quality of optical reconstruction remains a fundamental challenge in 3D computer holography, especially for the 3D diffraction fields with physically continuous and extensive depth range. Here, we propose a 3D computer-generated hologram (CGH) optimization framework with phase space tailoring. Based on phase space analysis of the space and frequency properties in both lateral and axial directions, the intensity of the 3D diffraction field is adequately sampled across a large depth range. This sampling ensures the reconstructed intensity distribution to be comprehensively constrained with physical consistency. A physics-informed loss function is constructed based on the phase space tailoring to optimize the CGH with suppression of vortex stagnation. Numerical and optical experiments demonstrate the proposed method significantly enhances the 3D optical reconstructions with suppressed speckle noise across a continuous and extensive depth range.

Near-field strong coupling and entanglement of quantum emitters for room-temperature quantum technologies

Daniel D. A. Clarke, Ortwin Hess

doi: 10.1186/s43074-024-00148-1

Abstract(10) PDF(0)

Abstract:
In recent years, quantum nanophotonics has forged a rich nexus of nanotechnology with photonic quantum information processing, offering remarkable prospects for advancing quantum technologies beyond their current technical limits in terms of physical compactness, energy efficiency, operation speed, temperature robustness and scalability. In this perspective, we highlight a number of recent studies that reveal the especially compelling potential of nanoplasmonic cavity quantum electrodynamics for driving quantum technologies down to nanoscale spatial and ultrafast temporal regimes, whilst elevating them to ambient temperatures. Our perspective encompasses innovative proposals for quantum plasmonic biosensing, driving ultrafast single-photon emission and achieving near-field multipartite entanglement in the strong coupling regime, with a notable emphasis on the use of industry-grade devices. We conclude with an outlook emphasizing how the bespoke characteristics and functionalities of plasmonic devices are shaping contemporary research directives in ultrafast and room-temperature quantum nanotechnologies.

Artificial potential field-empowered dynamic holographic optical tweezers for particle-array assembly and transformation

Xing Li, Yanlong Yang, Shaohui Yan, Wenyu Gao, Yuan Zhou, Xianghua Yu, Chen Bai, Dan Dan, Xiaohao Xu, Baoli Yao

doi: 10.1186/s43074-024-00144-5

Abstract(4) PDF(0)

Abstract:
Owing to the ability to parallel manipulate micro-objects, dynamic holographic optical tweezers (HOTs) are widely used for assembly and patterning of particles or cells. However, for simultaneous control of large-scale targets, potential collisions could lead to defects in the formed patterns. Herein we introduce the artificial potential field (APF) to develop dynamic HOTs that enable collision-avoidance micro-manipulation. By eliminating collision risks among particles, this method can maximize the degree of parallelism in multi-particle transport, and it permits the implementation of the Hungarian algorithm for matching the particles with their target sites in a minimal pathway. In proof-of-concept experiments, we employ APF-empowered dynamic HOTs to achieve direct assembly of a defect-free 8 × 8 array of microbeads, which starts from random initial positions. We further demonstrate successive flexible transformations of a 7 × 7 microbead array, by regulating its tilt angle and inter-particle spacing distances with a minimalist path. We anticipate that the proposed method will become a versatile tool to open up new possibilities for parallel optical micromanipulation tasks in a variety of fields.

引用排行

Terahertz spectroscopy in biomedical field: a review on signal-to-noise ratio improvement

Yan Peng, Chenjun Shi, Yiming Zhu, Min Gu, Songlin Zhuang

2020, 1(1). doi: 10.1186/s43074-020-00011-z

PDF(34)

Information Metamaterials: bridging the physical world and digital world

Qian Ma, Tie Jun Cui

2020, 1(1). doi: 10.1186/s43074-020-00006-w

PDF(61)

Recent advances in multi-dimensional metasurfaces holographic technologies

Ruizhe Zhao, Lingling Huang, Yongtian Wang

2020, 1(1). doi: 10.1186/s43074-020-00020-y

PDF(57)

Vacuum-ultraviolet photodetectors

Lemin Jia, Wei Zheng, Feng Huang

2020, 1(1). doi: 10.1186/s43074-020-00022-w

PDF(35)

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